Analysis of clinical features in pediatric morning glory syndrome

Abstract

Objective To analyze and summarize the clinical features and ocular fundus of pediatric patients with morning glory syndrome.Methods In this retrospective study, the clinical data of pediatric patients with morning glory syndrome, who were treated from June 2006 to June 2010 at the Department of Ophthalmology, Xinhua Hospital, including sex, age, right or left eye and visual acuity,were analyzed.Main outcome measures were best corrected visual acuity (BCVA),intraocular pressure,ocular fundus and dioptroscopy.Results Thirteen patients (14 eyes),7 males (54％) and 6 females (46％),were diagnosed with morning glory syndrome.They were diagnosed at an average age of (30.6±24.7)months (range from 2 months to 6 years of age).The syndrome presented in 6 left eyes (43％) and 8 right eyes (57％).Only one patient presented bilaterally.Visual acuity measurement was possible in 8 patients and their BCVA were all below 0.1.The ocular fundus of all patients' was exactly like a blooming morning glory.Four patients (4 eyes, 28％) had persistent hyperplastic primary vitreous,9 patients (9 eyes,64％) had heterotopia of the macula,while one patient (2 eyes, 14％) had retinal detachment.Conclusion Morning glory syndrome is a type of congenital deficiency syndrome that leads to severe visual impairment.Accurate and prompt diagnosis and regular follow-up is important for maintaining the visual acuity of these patients. Key words: Morning glory syndrome; Abnormal development of disc; Children