Abstract
ObjectiveThe clinical features of solitary pulmonary nodules (SPN) in breast cancer patients were retrospectively analyzed, and the clinical features of primary lung cancer (PLC) and metastatic pulmonary breast cancer (MBC) in breast cancer patients were compared, and the treatment plan, curative effect and influencing factors were analyzed.MethodsThe clinical data of 106 patients of SPN combined with breast cancer surgery in our hospital from January 2015 to June 2020 were analyzed. There were 65 patients of PLC and 41 patients of MBC. Record the characteristics of the primary breast cancer lesion in our patient, the interval between the initial diagnosis of breast cancer and the appearance of SPN, the previous treatment history of our patient, and the characteristics and surgical method of SPN. The survival status of all patients during the follow-up period was recorded.ResultsThe onset age, interval, maximum nodule diameter, ER expression positive rate and radiotherapy history ratio of PLC patients were higher than those of MBC patients, and the lymph node positive rate and triple negative rate were lower than those of MBC patients (P < 0.05). Median survival was 51 months in patients with PLC and 37 months in patients with MBC. The 1, 3, and 5 year overall survival rates in patients with PLC were higher than those in patients with MBC (P < 0.05). Vascular tumor thrombus, SPN type and chemotherapy were all independent factors affecting the prognosis of patients with breast cancer combined with SPN (P < 0.05).ConclusionPLC patients and MBC patients have significant differences in pathological characteristics, like the onset age, interval, maximum nodule diameter, ER expression positive rate, radiotherapy history ratio, the lymph node positive rate, and triple negative rate. Septum, vascular tumor thrombus, SPN type, and chemotherapy are all independent factors that affect the curative effect of breast cancer patients with SPN. Based on the nature of SPN, it can provide reference for clinicians to decide the treatment plan, improve patients' quality of life and prolong their survival time.
Highlights
Breast cancer is one of the most common malignant tumors in women, and its incidence is extremely high [1]
Multivariate analysis showed that interval, vascular tumor thrombus, the type of SPN, and chemotherapy were all independent factors affecting the prognosis of patients with breast cancer combined with SPN (P < 0.05) as shown in Tables 4, 5
Studies have shown that compared with the normal population, breast cancer patients are more likely to be accompanied by primary lung cancer (PLC), which may be related to the common genetic factors and hormone genes of the two diseases, and has a certain correlation with the survival time of breast cancer patients [10]
Summary
Breast cancer is one of the most common malignant tumors in women, and its incidence is extremely high [1]. Studies have shown that the primary malignant tumors secondary to breast cancer mainly include endometrial cancer, blood tumor, lung cancer, and so on [2]. It is the second most common primary cancer patients with breast cancer, and the lung is the common metastatic site of breast cancer [3, 4]. When finding SPN in breast cancer patients, the first clinical problem to be solved to accurately diagnose the nature of SPN and distinguish between primary lung cancer (PLC) and MBC, which is of great significance to guide breast cancer patients and SPN patients to choose the best individualized treatment scheme [6, 7]. We retrospectively analyzed the clinical characteristics of breast cancer patients with SPN, compared the clinical characteristics of PLC and MBC, and analyzed the efficacy of patients and the related factors affecting the prognosis of breast cancer patients with SPN, in order to provide clinical basis for the treatment and prognosis of breast cancer patients with SPN
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