Analysis of clinical characteristics of pediatric patients with central line-associated bloodstream infection in pediatric intensive care unit: a single-center retrospective study

Abstract

Objective To analyze the clinical characteristics and change in the infection rate of pediatric patients with hospital-acquired central line-associated bloodstream infection(CLABSI) in PICU, and identify the deficiencies in management, and learn from the experience of developed countries in preventing and controlling CLABSI. Methods The cases of CLABSI diagnosed in the PICU of Beijing Children′s Hospital from July 2014 to September 2017 were selected, the clinical information of the pediatric patients was collected, and the infection rate, the in-hospital mortality, and other indicators of CLABSI were calculated to clarify the clinical characteristics and infection status to improve the current practice standard. Results A total of 13 cases of CLABSI had femoral vein catheters.Among them, hematological tumors were the most common(4/13). The infection rate increased from 0.4 cases/1 000 catheter days in 2014 to 2.5 cases/1 000 catheter days in 2017, while the catheter utilization rate increased from 24.5% to 26.6%, children infected with Gram-negative bacteria were the most common(7/13)and the in-hospital mortality was 23.1%. Conclusion In recent years, the number of CLABSI cases has increased.The maximum sterile barrier measures should be supplemented to the current practice standards, the warning signs for catheter days should be added, and the necessity of indwelling catheter should be evaluated daily to reduce the rate of infection. Key words: Children; Intensive care unit; Health associated infections; Central line; Bloodstream infection