Analysis of clinical characteristics and medium-term prognosis of advanced elderly patients with mild ischemic stroke

Abstract

Objective To investigate clinical characteristics and medium-term prognosis of the advanced elderly patients with mild ischemic stroke, and to evaluate the risk factors for poor clinical outcome. Methods The 574 elderly patients with mild acute ischemic stroke admitted in neurology department of our hospital were retrospectively studied from January 2016 to December 2017.All cases were divided into the advanced elderly group(n=276, ≥80 years old)and elderly patient group(n=298, 60-79 years old). Clinical characteristics were analyzed.After 12-month follow-up, the mid-term prognosis and risk factors for poor clinical outcome(mRS≥3)were analyzed in the two groups. Results Compared with the elderly patients, the advanced elderly patients were more often complicated with history of atrial fibrillation, diabetes and stroke(P 0.05). After an average follow-up of(11.3±1.5)months, the proportions of poor clinical outcome and mortality were higher in the advanced elderly patients than in the elderly patients(63.4% or 175/276 vs.48.0% or 143/298, 25.7% or 71/276 vs.16.1% or 48/298, P<0.05). Cox proportional hazard model analysis showed that age, baseline NIHSS score and mRS score, diabetes and stroke history were the risk factors for poor clinical outcome in elderly patients with mild ischemic stroke(all P<0.05). Conclusions The advanced elderly patients with mild ischemic stroke have a severe clinical condition, higher rates of atrial fibrillation, diabetes and stroke history, and poor mid-term prognosis.Age, baseline scores of NIHSS and mRS, diabetes and stroke history are the risk factors for poor clinical outcome in elderly patients with mild ischemic stroke. Key words: Aged, 80 and over; Brain ischemic; Prognosis; Risk factors