Abstract
Type 1 diabetes mellitus, also called insulin-dependent diabetes is associated with elevated blood glucose concentration arising from the inability of the pancreas to produce insulin. Diabetic cardiomyopathy is a major cause of death in diabetic patients. CircRNAs have been reported to participate in various human diseases, including diabetic cardiomyopathy. In this study, the regulation network of circRNA in type 1 diabetes mellitus was investigated. Streptozotocin treatment was implemented to induce type 1 diabetes mellitus in the mouse model, and echocardiography was implemented to detect the heart function of the type 1 diabetes mellitus mouse. Also, the qRT-PCR assay was used to identify the circRNA expression in type 1 diabetes mellitus mouse myocardial tissue. Findings showed that heart function of type 1 diabetes mellitus mouse was significantly damaged than control group mouse and cardiac hypertrophy in type 1 diabetes mellitus mouse, circRNAs were aberrantly regulated in type 1 diabetes mellitus mouse myocardial tissue. The following circRNAs were mmu_circ_0001560, mmu_circ_0001800, mmu_circ_0001801, mmu_circ_0002281 and mmu_circ_0000614 were expressed low in type 1 diabetes mellitus mouse myocardial tissue. In conclusion, type 1 diabetes mellitus caused alterations in the regulation network of circRNAs.
Highlights
Diabetic cardiomyopathy occurs in diabetic patients and its potential reasons are not connected to hypertension, atherosclerosis and valvopathy diseases, but because of diabetes mellitus [1,2,3]
Findings showed that heart function of type 1 diabetes mellitus mouse was significantly damaged than control group mouse and cardiac hypertrophy in type 1 diabetes mellitus mouse, circRNAs were aberrantly regulated in type 1 diabetes mellitus mouse myocardial tissue
Results indicated that the heart function of the type 1 diabetes mellitus mouse was significantly (p
Summary
Diabetic cardiomyopathy occurs in diabetic patients and its potential reasons are not connected to hypertension, atherosclerosis and valvopathy diseases, but because of diabetes mellitus [1,2,3]. Diabetic cardiomyopathy can cause myocardial cells apoptosis and hypertrophy, and affect the normal function of myocardial cells [5]. Non-coding RNAs (ncRNAs) have been identified as involved in the regulatory network of various human diseases, such as cancer and diabetes mellitus [6, 7]. Circular RNA (circRNAs) was discovered as a new class of ncRNAs which was formed by a covalently closed loop [8, 9], and are stable in the cytoplasm of cells, playing a significant function in modulating the progression of human diseases [10-13]. We hypothesized that the circRNA regulatory network in diabetic cardiomyopathy could be studied for developing better treatment for diabetic cardiomyopathy patients
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