Abstract
A specific cytogenetic abnormality, an isochromosome 12p, i(12p), has been described in male germ cell cancers (Atkin and Baker 1982, 1983). The incidence of this abnormality has been stated to be as high as 90% (Heim and Mitelman 1987), occurring in tumors histopathologically diagnosed as seminoma, nonseminoma, and teratoma (Castedo et al. 1989a,b,c; Bosl et al. 1989; Samaniego et al. 1990). Our investigations of i(12p) in human germ cell cancer provide further support for the diagnostic importance of this cytogenetic marker. This review presents the molecular and cytogenetic studies from the Memorial Sloan-Kettering Cancer Center principally concerning chromosome 12 in primary and metastatic germ cell tumors and in established germ cell cancer cell lines.
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