Analysis of choroidal and central foveal thicknesses in acute anterior uveitis by enhanced-depth imaging optical coherence tomography

Mirinae Kim,Young-Hoon Park,Seung Yong Choi

doi:10.1186/s12886-017-0628-7

Mirinae Kim, Young-Hoon Park + Show 1 more

Open Access

https://doi.org/10.1186/s12886-017-0628-7

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Abstract

BackgroundCurrently, there are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). The aim of this study was to evaluate choroidal and central foveal thicknesses during episodes of AAU.MethodsThe medical records of 120 patients with AAU and 120 healthy subjects matched for age, sex, and spherical equivalent of refractive error were reviewed. Subjects were divided into group 1 (AAU-affected eyes), 2 (unaffected fellow eyes), and 3 (healthy control eyes).ResultsIn the uveitis group, etiologic diagnoses included human leukocyte antigen (HLA)-B27-associated (n = 71) and idiopathic (n = 49) AAU. The mean subfoveal choroidal thicknesses (SFCTs) in groups 1–3 were 326.7 ± 64.2, 296.1 ± 66.6, and 294.9 ± 41.7 μm, respectively. The corresponding mean central foveal thicknesses (CFTs) were 273.5 ± 29.3, 264.4 ± 24.6, and 263.0 ± 30.8 μm, respectively. The AAU group exhibited a significantly greater SFCT than the control groups (P < .001). Relative to the control group, while eyes with idiopathic AAU exhibited a significantly greater CFT, those with HLA-B27-associated AAU exhibited no such significant difference. Anterior chamber cell grade was not associated with SFCT or CFT.ConclusionsThe SFCT increased significantly during AAU. This indicates the importance of OCT examination for detection of subclinical choroidal and retinal changes in all types of AAU.

Highlights

There are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU)
Only patients with unilateral AAU who had Enhanced-depth imaging (EDI)-optical coherence tomography (OCT) data available for both eyes were included in the data analysis
There was no Discussion In this study, we observed significant increases in subfoveal choroidal and central foveal thicknesses during the active period of AAU

Summary

Introduction

There are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). Enhanced-depth imaging (EDI) OCT is a non-invasive technique, which can help visualize the choroidal structures. It provides in vivo, cross-sectional, histologic information of the choroid and allows visualization of choroidal vascular structures and measurement of. Some authors have reported that patients with active Vogt–Koyanagi–Harada disease exhibit a markedly thickened choroid [7,8,9]. In Fuchs’ uveitis syndrome, patients exhibit a relatively thin choroid, which might be the result of the chronic inflammation associated with the disease [11]

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