Abstract
Objective To discuss the predicting value of cervical intraepithelial neoplasias (CIN) Ⅰ with type Ⅲ transformation zone (TZ) had high grade cervical lesion. Methods From January 2007 and October 2009, 79 cases who were diagnosed as cervical intraepithelial neoplasias Ⅰ by histopathology in the People's Hospital of Jiangsu Province were recruited into this study. The cervical cytological examination showed ≥atypical squamous cell of undetermined significance (ASCUS), and high-risk human papilloma virus(HR-HPV) is positive. The histopathology was conducted after the loop electrosurgical excision procedure (LEEP), and histopathology changes were compared between colposcopic site-specific biopsies and loop electrosurgical excision procedure. Histopathological correlation were compared among preoperational cervical cytology, high-risk human papilloma virus load and loop electrosurgical excision procedure. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of People's Hospital of Jiangsu Province. Informed consent was obtained from all participants. Results ①For 79 cases, 53.16%(42/79, 53.16%) cervical intraepithelial neoplasias Ⅰ was graded up after loop electrosurgical excision procedure with 22 cervical intraepithelial neoplasias Ⅱ, 18 cervical intraepithelial neoplasias Ⅲ and 2 cervical cancer ⅠA1. ②The cytology positively correlated with the grade of cervical lesion (P 0.05). Conclusion Cervical intraepithelial neoplasias Ⅰ with type Ⅲtransformation zone is prone to omission of high-grade intraepithelial lesion. The cytology may help to predict the grade of cervical lesion. But the predicting value of high-risk human papilloma virus on the grade of cervical lesion may be inadequate. Key words: cervical intraepithelial neoplasias (CIN) Ⅰ; type Ⅲ transformation zone; high-risk human papilloma virus(HR-HPV); cytology
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