Abstract
The centrosome complex plays a fundamental role in cell division events. The centrosome, which nucleates and organizes all of the cellular microtubules, must be duplicated once, and only once, during each cell cycle. At the onset of M-phase the replicated daughter centrosomes then separate and move to opposite ends of the cell where the centrosomes serve as the spindle poles. in this capacity, the mitotic centrosomes nucleate the spindle microtubules that are responsible for chromosome segregation. Clearly, the fidelity of chromosomal segregation is dependent upon the regulated replication of the centrosome complex in each cell cycle.
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