Abstract
The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary ([Formula: see text]O2pulm), and muscular ([Formula: see text]O2musc) oxygen uptake during dynamic leg exercise across different body positions (-6°, 45°, and 75°). Ten healthy individuals [six men, four women; age 23.4±2.8years; height 179.7±8.3cm; body mass 73±12kg (mean±SD)] completed pseudo-random binary sequence (PRBS) work rate (WR) changes between 30 and 80W in each posture. HR was measured beat-to-beat by echocardiogram and [Formula: see text]O2pulm by breath-by-breath gas exchange. [Formula: see text]O2musc kinetics were assessed by the procedure of Hoffmann et al. (Eur J Appl Physiol 113:1745-1754, 2013) applying a circulatory model and cross-correlation functions (CCF). For [Formula: see text]O2pulm kinetics significant differences between -6° (CCF-values: 0.292±0.040) and 45° (0.256±0.034; p<0.01; n=10) as well as between -6° and 75° (0.214±0.057; p<0.05; n=10) were detected at lag '40s' of the CCF course as interaction effects (factors: Lag×Posture). HR and [Formula: see text]O2musc kinetics yield no significant differences across the postures. The analysis of cardio-dynamic and respiratory kinetics, especially with an emphasis on muscular and cellular level, has to consider venous return and cardiac output distortions. Simplified observations of kinetics responses resulting in time constants and time delays only should be replaced by the time-series analysis for a more sophisticated evaluation. The results illustrate that isolated [Formula: see text]O2pulm measurements without cardio-dynamic influences may not represent the kinetics responses originally revealed at muscular level.
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