Analysis of Bronchoscopy on Acute Exacerbation of Pulmonary Emphysema Chronic Obstructive Pulmonary Disease Using CT Chest Imaging

Abstract

Purpose: To understand the role of bronchoscopy in the treatment of chest CT images for patients with acute exacerbation of emphysema phenotype chronic obstructive pulmonary disease (COPD). Methods: 89 cases with chest CT images suggesting acute exacerbation of emphysema phenotype COPD were included and divided into the experimental group and the control group according to whether underwent bronchoscopy. Arterial blood gas indexes (pH value, PaO2, PaCO2), total glucocorticoid usage, length of stay, serum inflammatory factors (TNF-α, IL-6, IL-10) before and after treatment were compared between the two groups. Results: The hospitalization time of the experimental group was significantly shorter than that of the control group (11.88 ± 8.61 d vs. 16.50 ± 12.15 d, P = 0 045); the total use of methylprednisolone test group was 213.66 ± 32.07mg, and the control group was 250.83 ± 102.55 mg. The difference between the two groups was statistically significant (P = 0 028). The trend of repeated analysis of variance (F = 12 11,P = 0 001) were statistically significant. PaCO2 significantly decreased before and after the test in the experimental group (49.40 14.85 mmhg vs. 43.30 12.48 mmhg, P = 0.000). Plasma TNF-α and IL-6 decreased and IL-10 increased before and after the test. TNF-α and IL-6 increased and IL-10 decreased before and after the control group test, and the changes and trends of TNF-α, IL-6 and IL-10 before and after the two groups were statistically different (P = 0.000). These symptoms can be analyzed using CT imaging. Conclusion: In patients with acute exacerbation of emphysema phenotype COPD who are initially ineffective, bronchoscopy, alveolar lavage, and anti-contamination brush sampling guide anti-infective treatment can improve patient ventilation, and reduce glucocorticoid consumption.