Analysis of breast cancer screening results in urban areas of Henan Province.

Abstract

10543 Background: Breast cancer is the most common female cancer in China. Reasonable and effective screening is an important means to reduce the mortality of breast cancer. This study was to evaluate the compliance and efficacy of breast cancer screening in urban areas of Henan province from 2013 to 2019. Methods: A cluster sampling method was used to select the residents of 40-74 years old in Henan province to investigate the risk factors and breast cancer risk assessment. For subjects with high risk of breast cancer, those aged 40-44 conduct breast ultrasound examination; those aged over 45 conduct breast ultrasound combined with mammography examination. BI-RADs classification was used as the evaluation standard in both examinations. BI-RADS 3 class was defined as suspicious and BI-RADS≥4 class was defined as positive. Chi-square test was used to analyze the compliance rate and breast cancer detection rate among different groups. Results: A total of 29 111 residents at high risk for breast cancer were recruited in this study. They were 55.03 ± 7.91 years old, of which 13 760 took the following breast ultrasound or mammography examination, yielding a participation rate of 47.27% (13 760/29 111). The detection rates of suspected positive patients, positive patients and breast cancer patients were 23.40% (3 220/13 760), 2.55% (351/13 760) and 0.30% (41/13 760), respectively. Among the screening population, the highest detection rate of suspected positive patients was found in the 45-49 age group [27.79% (935/3 365)], the highest detection rate of positive patients was found in the 50-54 age group [2.98% (97/3 257)], and the highest detection rate of breast cancer was found in the 65-69 age group [0.49% (5/1 012)]. The detection rate of breast cancer positive patients by breast ultrasound combined with mammography examination was 2.95% (316/10 728), which was significantly higher than that of breast ultrasound alone [1.99% (213/10 728)] or mammography examination alone [1.25% (134/10 728)]. Conclusions: Breast ultrasound combined with mammography examination as a means of screening for breast cancer can significantly increase the detection rate of breast cancer positive patients. The next step should be to improve the compliance of the population, as well as the organization's implementation and service capabilities of the screening provider, to improve screening effectiveness.