Analysis of brain functional connectivity network in MS patients constructed by modular structure of sparse weights from cognitive task-related fMRI.

Abstract

Cognitive dysfunction in multiple sclerosis (MS) seems to be the result of neural disconnections, leading to a wide range of brain functional network alterations. It is assumed that the analysis of the topological structure of brain connectivity network can be used to assess cognitive impairments in MS disease. We aimed to identify these brain connectivity pattern alterations and detect the significant features for the distinction of MS patients from healthy controls (HC). In this regard, the importance of functional brain networks construction for better exhibition of changes, inducing the improved reflection of functional organization structure should be precisely considered. In this paper, we strove to introduce a framework for modeling the functional connectivity network by considering the two most important intrinsic sparse and modular structures of brain. For the proposed approach, we first derived group-wise sparse representation via learning a common over-complete dictionary matrix from the aggregated cognitive task-based functional magnetic resonance imaging (fMRI) data of all subjects of the two groups to be able to investigate between-group differences. We then applied the modularity concept on achieved sparse coefficients to compute the connectivity strength between the two brain regions. We examined the changes in network topological properties between relapsing-remitting MS (RRMS) and matched HC groups by considering the pairwise connections of regions of the resulted weighted networks and extracting graph-based measures. We found that the informative brain regions were related to their important connectivity weights, which could distinguish MS patients from the healthy controls. The experimental findings also proved the discrimination ability of the modularity measure among all the global features. In addition, we identified such local feature subsets as eigenvector centrality, eccentricity, node strength, and within-module degree, which significantly differed between the two groups. Moreover, these nodal graph measures have been served as the detectors of brain regions, affected by different cognitive deficits. In general, our findings illustrated that integration of sparse representation, modular structure, and pairwise connectivity strength in combination with the graph properties could help us with the early diagnosis of cognitive alterations in the case of MS.