Abstract
In the present study, we analyzed bovine leukemia virus (BLV) integration sites in under 3years old with enzootic bovine leukosis (EBL) cattle and compared these to 30 cattle over 3years old with EBL. BLV proviruses were integrated near CpG islands and into long interspersed nuclear elements more frequently in EBL cattle under 3years old than in those over 3years old. These results suggest that cattle under 3years old with EBL have different BLV provirus integration sites from those of cattle over 3years old with EBL, and the BLV provirus integration site may represent one factor contributing to early onset of EBL.
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