Abstract
To investigate the impact of bone mesenchymal stem cells (BMSCs) intervention on the viscoelasticity of sciatic nerve in rats with chronic alcohol intoxication (CAI). The CAI rat models were prepared, divided into model groups, and treated with either BMSCs or basic fibroblast growth factor (bFGF). Then the rats underwent electrophysiological test and the serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), and metallothionein (MT) were measured. Histological observation, stress relaxation test, and creep test were performed for the sciatic nerve of the CAI model in each group. The MDA level of group BMSC was significantly lower (p<0.05) than that of groups MOD (the CIA model) and bFGF. The SOD and MT levels were higher in group BMSC than in groups MOD and bFGF (p<0.05). The motor nerve conduction velocity and amplitude were higher in group BMSC than in groups MOD and bFGF (p<0.05). The amounts of 7200s stress reduction and 7200 s strain increase of the sciatic nerve in group BMSC were greater than those in groups bFGF and MOD (p<0.05). Bone mesenchymal stem cells can improve the metabolism of free radicals, restore the tissue morphology and viscoelasticity of the chronic alcohol intoxication animal model, and positively affect the repairing of the injured sciatic nerve.
Highlights
Long-term effects of alcohol abuse can cause direct damage to the brain and liver as well as nervous system damage, resulting in judgment decline, emotional numbness, insight weakening, family discord, interpersonal tension, and other social problems[1,2,3]
The electrophysiological results showed that the motor nerve conduction velocity (MNCV) and amplitude of group bone marrow mesenchymal stem cells (BMSCs) were higher than those of groups MOD and basic fibroblast growth factor (bFGF) (p
It means that alcoholism caused sciatic nerve injury in rats, and the intervention of BMSCs and bFGF helped recover from such injury (Table 1)
Summary
Long-term effects of alcohol abuse can cause direct damage to the brain and liver as well as nervous system damage, resulting in judgment decline, emotional numbness, insight weakening, family discord, interpersonal tension, and other social problems[1,2,3]. Tan et al.[8] believe that alcohol intoxication (AI) causes functional and structural damages in the peripheral nerves and results in peripheral neuropathy, which is related to the changes in membrane fluidity as well as in membrane ion channels and oxygen free radical production. Aebischer et al.[11] bridged sciatic nerve defects, 15 mm and 7 mm in length, in rats by treating with bFGF for 4 weeks. They found that the nerve regeneration was successful, which is consistent with that by the intervention of bFGF in the central nervous system. We hypothesized that BMSC transplantation would restore the viscoelastic properties of the sciatic nerve in CAI and repair sciatic nerve injury to a certain extent. This study aimed to verify our hypothesis and the property of viscoelasticity for clinical rehabilitation of sciatic nerve injury
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