Analysis of blood gas composition indicators in premature babies with neonatal sepsis

Olena Vlasova,Larysa Kolyubakina

doi:10.15587/2519-4798.2020.209147

Olena Vlasova, Larysa Kolyubakina

Open Access

https://doi.org/10.15587/2519-4798.2020.209147

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Abstract

The aim of the study was analysis of oxygen status of patients with neonatal sepsis during monitoring of premature infants.Materials and methods. Indicators of oxygen status of capillary blood were assessed in premature infants with neonatal sepsis who were treated at the Regional Perinatal Center in Khmelnytsky during 2017–2018. The study included mostly deeply premature babies, including those with extremely low weight. A full range of clinical and laboratory studies, including determination of oxygen status of capillary blood.Research results. Our results allow us to conclude that while such indicators as pH, pO2, BEb3, % SO2 do not change significantly, the trouble can be detected using indicators such as AdDO2, RI, PI, which reflect the state of oxygenation with impaired ventilation. -perfusion ratios, increased blood shunting and the processes of delivery and consumption of oxygen at the tissue level. The calculated indicator "PIP×FiO2" was less sensitive to assess changes in the lungs and did not correspond to the clinical picture of the severity of the patient's condition.Conclusion. Thus, the determination of AdDO2, RI, PI capillary blood can be used as informative indicators for determining the oxygen status in premature infants, which is of significant practical importance in terms of limited monitoring of the gas composition of arterial blood

Highlights

Newborns who are in a serious condition, quite often get disorders of vital functions of the body, which are embedded in the concept of systemic inflammatory response syndrome
Materials and methods Indicators of the oxygen status of capillary blood were assessed in 17 premature infants with neonatal sepsis who were treated at the Regional Perinatal Center in Khmelnytsky during 2017–2018
Homogeneity of the group by gestational age and birth weight allowed to exclude the influence of these indicators on the degree of maturity of the respiratory and central nervous system, the formation of bronchopulmonary dysplasia, duration of mechanical ventilation, oxygen status of capillary blood

Summary

Introduction

Newborns who are in a serious condition, quite often get disorders of vital functions of the body, which are embedded in the concept of systemic inflammatory response syndrome. Assessment of the severity of organ disorders, dynamic monitoring of the patient’s condition and the need for correction of therapeutic measures in neonatal sepsis is one of the important tasks in predicting both the immediate and long-term consequences of the disease. A review of the literature [9, 10] confirms that capillary blood parameters can be used to assess the oxygen status of premature infants. The composition of capillary blood reflects the function of the lungs, and associated with the processes of delivery and consumption of oxygen to tissues

Methods

Results

Conclusion