Abstract

The review demonstrates an application of methods of statistical thermodynamics for the analysis of binding of ligands to DNA and RNA. Reversible binding of ligands to nucleic acids is considered on the basis of the theory of adsorption. The binding of ligands to nucleic acids allows of describing quantitatively the process of binding and simulate the expression of genes in the simplest organisms. Description of the binding of ligands to nucleic acids is currently used in the broadest context for experimental systems of different types. Modern methods of biotechnology like molecular design or the use of microarrays are based on analysis of the binding of ligands to nucleic acids.

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