Abstract
ABSTRACTHistorically some barbiturates have been difficult to differentiate by quadrupole mass spectrometry. Ion trap mass spectrometry was investigated to determine its discriminating ability.A comparison between Electron Ionization (El) obtained from ion trap and quadrupole detectors is documented. Twenty-two barbiturates were analyzed on both the ion trap and quadrupole detectors at a concentration of 10 ng/μL.The spectra obtained from the different detectors are similar in appearance with one notable difference being an ion indicating molecular weight. At the concentration used in this study, thirteen spectra obtained from the quadrupole contain no molecular ion. However, a protonated fnolecular ion (M + 1) is present in all spectra using the ion trap. This feature allows secobarbital to be easily distinguished from talbutal, aprobarbital, and butalbital using the ion trap detector. These barbiturates have similar base peaks and prominent ions but different molecular weights.No significant differences...
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