Abstract
It is interesting to note that the adverse effect of this genotype was observed exclusively in patients with ronchopathy, while in patients with ronchopathy, the frequency of this genotype did not differ in comparison with the control group, i.e. there is a significant tendency to an increase in the genotype with an increase in the severity of the pathology. Material and methods. To solve the set tasks, 208 patients with various diseases of the upper respiratory tract, with nasal breathing disorders, causing ronchopathy, who were hospitalized in the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy for 2015 to 2021, were examined. The control group consisted of 50 apparently healthy people who agreed to participate in the study (students, masters, clinical residents). Among the sick men there were 144 (73%), women - 64 (27%). The age of the patients ranged from 18 to 70 years, averaging 44.5 ± 6.8 years. Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the RSNPMC Hematology. This part of the work consisted of several stages: 1. Blood sampling. 2. Isolation of DNA from peripheral blood lymphocytes. 3. Carrying out PCR. 4. Conducting electrophoresis and visualizing the results (if necessary). The analysis of the TGFb1 gene polymorphism associations was carried out using a case-control model (casecontrol, comparison of two samples). The sample "case" was formed from 104 patients with ronchopathy. Conclusion. Since this work is one of the few works on the study of the relationship between rs 2010963 of the VEGFA gene and the risk of developing ronchopathy, our data may become the subject of further discussions.
Highlights
Ronchopathy - synonyms for primary snoring, pathological snoring, snoring [1,2].Manuscript received on July 14, 2021
The analysis of the TGFb1 gene polymorphism associations was carried out using a case-control model
Since this work is one of the few works on the study of the relationship between rs 2010963 of the VEGFA gene and the risk of developing ronchopathy, our data may become the subject of further discussions
Summary
Ronchopathy - synonyms for primary snoring (benign, simple, normal), pathological snoring (chronic, regular, habitual, unusual), snoring [1,2]. In many cases, snoring is underestimated, resulting in a failure to diagnose comorbid conditions such as obstructive sleep apnea (OSA). It is a multifactorial disease in which histological changes, rheological parameters and predisposing factors such as high body mass index, age and male sex play an important role, which lead to disturbed sleep and affect quality of life, significantly increasing the risk of cardiovascular morbidity. No research methodology has been developed that allows one to assess the functional and morphological state of the nasal mucosa in normal conditions, with ronchopathy and obstructive sleep apnea syndrome at the examination stage, and thereby determine the choice of rational treatment tactics for this pathology. The search for objective methods for studying the functional state of the nasal cavity and standardizing the results of the study of nasal breathing remains an urgent problem of otorhinolaryngology, which determined the purpose of this study
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