Abstract
Bronchial asthma is a multifactorial disease underpinned by chronic inflammation. The atopic phenotype of BA implies the presence of similar molecular mechanisms of pathogenesis between the patients. The aim of this study was to analyze the associations between the development of atopic BA/its remission and the following polymorphisms of interleukin genes: IL4 (rs2243250; C-589T), IL10 (rs1800896; G-1082A; rs1800872; C-592A), and IL13 (rs20541; Arg130Gln). Using allele-specific polymerase chain reaction (PCR), we studied the listed SNPs in the mixed urban sample of patients with BA (n = 53) and the controls (n = 30) residing in South Ural. The analysis revealed that genotype АА of IL10 (rs1800872) occurred more frequently in the control group (23.3%) than in the patients with atopic BA (5.7%) (OR = 0.197; 95% CI [0.047–0.832]; р = 0.031). No differences in genotype frequencies were observed between the patients with atopic BA and the controls for other studied polymorphisms. Our study failed to demonstrate the association of the listed polymorphisms and BA remission.
Highlights
Bronchial asthma is a multifactorial disease underpinned by chronic inflammation
The aim of this study was to analyze the associations between the SNPs in the genes coding for IL4, IL10, IL13 and the development of atopic Bronchial asthma (BA) /its remission in the mixed sample of Chelyabinsk (South Ural) residents
Previous metanalyses demonstrated an association between the polymorphism C-589T of the IL4 gene and the risk for BA in the European population [20] and another association between the polymorphism Arg130Gln of the IL13 gene and an increased risk for BA in children and adults [21,22,23]
Summary
Bronchial asthma is a multifactorial disease underpinned by chronic inflammation. The atopic phenotype of BA implies the presence of similar molecular mechanisms of pathogenesis between the patients. No differences in genotype frequencies were observed between the patients with atopic BA and the controls for other studied polymorphisms. Целью работы было провести анализ ассоциации полиморфных локусов генов IL4 (rs2243250; C-589T), IL10 (rs1800896; G-1082A; rs1800872; C-592A), IL13 (rs20541; Arg130Gln) с развитием атопической БА и ремиссией. Анализ ассоциации полиморфных вариантов генов интерлейкинов с развитием БА показал, что генотип АА IL10 (rs1800872) встречается чаще в группе сравнения (23,3%), чем в группе атопической БА (5,7%) (ОШ = 0,197; 95% ДИ [0,047–0,832]; р = 0,031). Для остальных исследованных полиморфных локусов генов интерлейкинов отличий в частотах генотипов между больными атопической БА и группой сравнения не обнаружено. С. Абрамовских — методика и курирование исследования, анализ и интерпретация данных, написание и оформление статьи; Г. Все участники подписали добровольное информированное согласие на участие в исследовании
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
