Analysis of Associations between 5-HTT, 5-HTR2A, and GABRA6 Gene Polymorphisms and Health-Associated Personality Traits

Abstract

The development of personality traits united by the notion of conscientiousness, should promote, along with reduction of anxiety, the physical and mental health. In order to detect the sources of conscientiousness and neuroticism formation, we evaluated associations between polymorphic markers of 5-HTT, 5-HTR2A, and GABRA6 genes and relevant scores of TCI questionnaire in a group of 369 volunteers. Associations of markers VNTR and LPR of 5-HTT gene and marker T1521C of GABRA6 gene with "self-directedness" and the effects of 5-HTR2A gene marker T102C and its interactions with the GABRA6 gene on the "harm avoidance" were detected.