Analysis of association between violent behavior and the polymorphism of monoamine oxidase A

Abstract

Objective To investigate the association between monoamine oxidase A ( MAOA) gene rs5906893, rsl 137070 polymorphism and violent behavior. Methods The methods of PCR-restriction fragment length polymorphism (RFLP)was conducted to detect rs5906893 and rsl 137070 single nucleotide polymorphism loci of MAOA gene of in a 92 prison staff ( case group) and 101 normal controls ( control group) . The association between the polymorphisms and violent behavior was analyzed with SPSS13.0. The UNPHASED program was applied to perform the combined effect analysis of the paired SNPs. Results MAOA gene rs5906893 of CC genotype frequency in the case group and the control group were 63. 0% and 63. 4% ,TT genotype frequency were 37. 0% and 36.6% , no significant differences were found between the two groups (P>0.05). MAOA gene rsl 137070 of CC genotype frequency were 40.2% and 36.6% ,TT genotype frequency were 59. 8% and 63.4% ,and no significant differences were found between the case and the control (P>0. 05). The results of the combined effect analysis showed that rs5906893-rsl 137070 was associated with violent behavior(P=0.002 ). Conclusion MAOA gene rs5906893, rs1137070 polymorphism may be not associated with violent behavior. But the combined effect analysis showed that the haplotype of the paired SNPs was associated with violent behavior. Key words: Violent behavior; Monoamine oxidase A; Single nucleolide polymorphism (SNP)