Abstract
Today it is well known that protein-coding genes account for only 3% of the total active transcript
Highlights
Today it is well known that protein-coding genes account for only 3% of the total active transcript
It was found that minor T-alleles homozygotes had significantly lower risk of prostate cancer development compared to C-allele carriers (ORc = 0.161; 95% confidence interval (CI) = 0.047-0.555; Pc = 0.004) and C-allele homozygotes (ORc = 0.168; 95% CI = 0.048-0.589; Pc = 0.005)
After adjusting for age, smoking status and body mass index (BMI) the overall picture of the results did not change: ORa = 0.164; 95% CI = 0.047-0.577; Pa = 0.005 – for recessive model; ORa = 0.170; 95% CI = 0.048-0.609; Pa = 0.006 – for additive model
Summary
Today it is well known that protein-coding genes account for only 3% of the total active transcript. Non-coding RNAs that contain 200 or more nucleotides in their structure are called long non-coding RNA (lncRNA) and represent the largest fraction of all ncRNAs. In the living organism cells lncRNAs are involved in the processes of transcription, translation, epigenetic regulation of gene expression, inactivation of the X chromosome, cell differentiation, etc. MALAT1 gene is located on the plus-chain of the 11th chromosome (11q13.1), consists of more than 8,000 bases pairs and contains 2 exons [5]. The results of several studies have demonstrated the presence of MALAT1 in the nuclear paraspeckles, indicating its involvement in mRNA processing [6]. MALAT1 was firstly identified as metastasis prognostic factor in patients with non-small cell lung cancer [8], but more recent studies have demonstrated significant
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