Analysis of association between RAGE polymorphisms and stroke risk

Abstract

Receptor for advanced glycation end products (RAGE) is a kind of immunoglobulins that interacts with several ligands and participates in regulation of immune responses. Variants within RAGE gene have been associated with risk of stroke in different populations. In the present study, we have assessed associations between two single nucleotide polymorphisms (SNPs) in this gene and risk of ischemic stroke in Iranian persons by using tetra primer-amplification refractory mutation system-PCR approach. Totally, 184 patients with history of ischemic stroke and 192 age- and sex-matched controls were recruited. After correction for multiple comparisons, there were no significant difference in allele frequencies of rs184003 and rs1800625 between cases and controls (P values of 0.38 and 0.06 respectively). A significant association was found between rs1800625 genotypes and risk of stroke in recessive and additive models (OR (95% CI) = 0.2 (0.04–0.93), adjusted P value = .04; OR (95% CI) = 1.52 (1.04–2.21), P value = .03 respectively) which implies that CC genotype has a protective role against stroke in the assessed population when compared with TT + CT genotypes. The estimated haplotypes distributed similarly between cases and controls. Our data propose a role for RAGE variants in modulating the risk of stroke in Iranian population. However, our data need to be appraised in larger cohorts of patients.