Abstract
Introduction. Analytical method development is increasingly being introduced into fundamental pharmaceutical research, taking into account their high sensitivity, accuracy, specificity and expressiveness. Search criteria was analytical method development for bisoprolol. Literature survey was done in range of years 1990–2018 to make the review updated and comprehensive and to show the new approaches to the development of the methods of analysis of bisoprolol. The sources were world recognized journals and key words used as filter were bisoprolol, method development, validation, spectrophotometry, HPLC, UHPLC. The current review is created with an intention to focus on the advantage of HPLC. However, there is very few analytical methods reported for the simultaneous analysis of these drugs in a combined dosage formulation by HPLC. In additional, analysis of approaches to the development of the methods of analysis of bisoprolol in drugs and biological liquids has been shown that HPLC is the most suitable method for analyses of bisoprolol in substances, drugs, biological liquids to perform routine analysis of medicines, pharmacokinetic (bioequivalence in vivo), dissolution test for final dosages forms (bioequivalence in vitro, biowaiver procedure). The aim of the study – to analyze approaches to the development and validation of the methods of analysis of bisoprolol in drugs and biological liquids. Conclusions. In light of the benefits discussed in this review, we can conclude that analysts are constantly working on developing new methods of analysis of bisoprolol in drugs and biological liquids and on their optimization in order to save time and consumables, which also ensures the efficiency of the developed methodology. Literature survey revealed that a number of methods have been reported for estimation of bisoprolol individually or in combination with other drugs. However, there is very few analytical methods reported for the simultaneous analysis of these drugs in a combined dosage formulation by HPLC.
Highlights
Analytical method development is increasingly being introduced into fundamental pharmaceutical research, taking into account their high sensitivity, accuracy, specificity and expressiveness
In light of the benefits discussed in this review, we can conclude that analysts are constantly working on developing new methods of analysis of bisoprolol in drugs and biological liquids and on their optimization in order to save time and consumables, which ensures the efficiency of the developed methodology
Literature survey revealed that a number of methods have been reported for estimation of bisoprolol individually or in combination with other drugs
Summary
Analytical method development is increasingly being introduced into fundamental pharmaceutical research, taking into account their high sensitivity, accuracy, specificity and expressiveness. Search criteria was analytical method development for bisoprolol. Literature survey was done in range of years 1990–2018 to make the review updated and comprehensive and to show the new approaches to the development of the methods of analysis of bisoprolol. The sources were world recognized journals and key words used as filter were bisoprolol, method development, validation, spectrophotometry, HPLC, UHPLC. There is very few analytical methods reported for the simultaneous analysis of these drugs in a combined dosage formulation by HPLC. The aim of the study – to analyze approaches to the development and validation of the methods of analysis of bisoprolol in drugs and biological liquids
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