Abstract
Canine distemper virus (CDV) is prevalent among domestic dogs and causes disease in various types of carnivores worldwide. In the present study, the genotype of two CDV strains, namely, ZJJSD and ZJJ-LN, were investigated based on the whole hemagglutininatinine (HA) antigen gene. The CDV strains were obtained from two foxes in Shangdong province and Liaoning province of Short Research Article Wang et al.; BMRJ, 8(1): 367-378, 2015; Article no.BMRJ.2015.129 368 China in 2011. Before now phylogenic analysis had been carried out for only 260 CDV strains, worldwide and an analysis was performed in the amino acid substitutions at positions 530 and 549 of the HA protein. Phylogenetic analyses revealed that the two strains, ZJJ-SD and ZJJ-LN, belonged to the CDV Asia I lineage. Site 530 of HA protein was found to be relatively conserved within CDV lineages in different host species by combining the genetic sequence data with the published data from 260 CDV strains worldwide. The data analysis showed a bias toward the predicted substitution Y549H for the non-dog strains in Asia I and Europe lineages. The strain ZJJSD, from wild canid, has a Y549H substitution. It is one of three Y549H substitution for wild canids in Asia I lineages.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
