Abstract
Three analogs of arterenol were comparatively studied on several effector systems in dogs. The amines were: ( a ) ethylnorepinephrine (butanephrine), ( b ) isoproterenol (Isuprel), and ( c ) the N-isopropyl derivative of ethylnorepinephrine (Win-3046). These amines were compared to levarterenol and epinephrine as to potency and effect on arterial pressure, heart rate, intestinal motility, splenic capsule, and urine output. The effects on the splenic capsule best illustrates the general relationships found. Epinephrine, levarterenol, and ethylnorepinephrine produce primary splenic contraction; this effect is prevented by adrenergic blockade and is not modified by ganglionic blockade. Compounds ( b ) and ( c ), and ( a ) to some extent, induce a reflex splenic contraction by their depressor action. This effect is prevented by either adrenergic or ganglionic blockade. When administered simultaneously with epinephrine, ( b ) and ( c ) diminish the splenic contraction produced by the epinephrine.
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