Abstract
The identification of camitine esters in the urine is important in the diagnosis of metabolic diseases which alter camitine metabolism [l]. Their quantitation may also give clues to the physiological role of carnitine in the metabolism of branched chain amino acids and fatty acids, the influence of nutrition on these processes and the possible function of camitine in the conjugation of potentially toxic endogenous or exogenous organic acids. The excretion of total, free and acylcamitine [2-41 and that of acetylcamitine [5] in healthy humans has been measured in several studies. However, the analysis of individual camitine esters in normal human urine has been incomplete due to a lack of methods sensitive and specific enough to detect low concentrations of these compounds. In the following, we report the quantitation of camitine esters in normal human urine using a modification of the radioisotopic exchange-HPLC method originally described by Kemer and Bieber for tissue extracts and colostrum WI.
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