Analysis of abnormal glucose metabolism in acute coronary syndrome patients without diagnosed diabetes mellitus in Han, Uygur and Kazak people in Xinjiang China

Abstract

Objective To investigate the abnormal glucose metabolism in acute coronary syndrome (ACS) inpatients without diagnosed history of diabetes mellitus (DM) of Han, Uygur and Kazak people in Xinjiang. Methods Five hundred and eighty-one ACS cases without DM were collected from September 2010 to September 2012 in three ethnic inpatients.Oral glucose tolerance (OGTT) were underwent to determine the glucose metabolism if they could not be clearly diagnosed as diabetes by fasting plasma glucose. Results Total of 428 cases (73.7%) had abnormal glucose metabolism, including 245 patients (42.2%) with DM and 183 cases (31.5%) with abnormal glucose regulation. There were 337 Han cases with ACS, including 146 cases (43.3%) with diabetes mellitus and 114 cases (33.8%) with glucose regulation abnormality. There were 219 Uygur cases, including 96 cases (43.8%) with DM and 65 cases (29.7%) with abnormal glucose regulation. There were 25 Kazak cases, including 3 cases (12.0%) with DM and 4 cases (16.0%) with abnormal glucose regulation. Without OGTT test, only recognized by fasting blood glucose, 38.0% diabetes mellitus patients would be missed and 43.7% impaired glucose regulation patients would be missed in patients without diagnosed history of DM. There was no statistically significant difference in follow-up after 3 months (P<0.05). Conclusion There are 428 cases (73.7%) with abnormal glucose metabolism in Han, Uygur and Kazak ACS patients without diagnosis history of DM in Xinjiang, and the incidence is the lowest in kazak patients.Only relying on fasting blood glucose, a considerable number of ACS patients with abnormal glucose metabolism would be missed. Key words: Acute coronary syndrome; Diabetes mellitus; Impaired glucose regulation; Oral glucose tolerance test