Abstract
The steady-state performance of a recycle two-stage fermentor with cell separators after each stage is studied numerically for continuous production of acetic acid. This system has two fresh-medium feed streams and the bleed withdrawn from the first stage is supplied to the second fermentor for utilization of the high cell concentration in the bleed. Kinetic expressions and parameter values are taken from the literature. The effects of operating parameters on the concentrations of cells, substrate and product in the two stages, the critical dilution rate for washout, the acetic acid productivity and the substrate conversion are examined and discussed. For overall productivity and conversion, the present two-stage system is found to be more efficient than a recycle chemostat and a recycle two-stage fermentor with a separator after the final stage. It exhibits sufficient promise for the continuous production of acetic acid that it should be tried out experimentally.
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