Abstract
The feasibility of containing microencapsulated urease within a fludized-bed reactor, eliminating problems of membrane rupture, was demonstrated. Hydrolysis of urea under conditions simulating that of an artificial kidney device was measured as a function of reactor residence time, microcapsule diameter, volume of microcapsules, urea concentration in the feed, and enzyme activity. Empirical correlations were developed based on dimensional analysis, which may be used to predict urea conversion within the range of experimental operating conditions. Results under transient state conditions better represent the operation of the reactor in treatment of uremic patients.
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