Analysis of 78 trace liquid crystal monomers in air by gas chromatography coupled with triple quadrupole mass spectrometry

Abstract

Liquid crystal monomers (LCMs) comprise a class of organic pollutants that have garnered considerable attention because of their dioxin-like toxicity (i.e., modulation of genes) and presence in various environments. However, limited information about the identities, occurrence, and distribution of LCMs has highlighted an urgent need for a high-throughput and sensitive analytical method. In this study, we developed and validated a rapid, simple, sensitive method that involves minimal solvent consumption. The method was applied for the simultaneous detection and identification of 78 LCMs in atmospheric total suspended particulate samples (dae < 100 μm) using gas chromatography coupled with triple quadrupole mass spectrometry. The results showed high degrees of linearity with correlation coefficients >0.995 in the concentration range of 5.0–500 ng/mL. The instrumental detection limits ranged from 0.7 to 5.3 pg, and the method detection limits ranged from 0.1 to 0.9 pg/m3. The accuracy of the method was between 70 % and 130 % for most analytes, and the relative standard deviations of six replicates were <15 % at three levels of spiking (10, 50, and 200 ng/mL). The developed analytical method was applied to analyze real air particulate samples from Beijing, China. Overall, 45 LCMs ranged from 65.5 to 145.7 pg/m3, with a mean concentration of 92.5 pg/m3. Among them, (trans,trans)-4-propyl-4′-ethenyl-1,1′-bicyclohexane (PVB) was the most abundant, with an average concentration of 33.6 pg/m3. The total estimated daily intakes of LCMs for adults and children were 15.6 and 46.6 pg/kg bw/day, respectively. Accordingly, the method described herein is suitable for quantifying LCMs in atmospheric particulate samples. This study will be valuable for investigating LCM environmental occurrence, behaviors, and risk assessments.