Analysis of 472,688 Severe Cases of COVID-19 in Brazil Showed Lower Mortality in Those Vaccinated against Influenza

Daniele Melo Sardinha,Ana Lúcia Da Silva Ferreira,Karla Valéria Batista Lima,Diana Da Costa Lobato,Luana Nepomuceno Gondim Costa Lima,Ricardo José De Paula Souza E Guimarães

doi:10.4236/wjv.2021.113004

Abstract

Objective: To analyze the severe cases of COVID-19 in Brazil in 2020 and compare those vaccinated and unvaccinated against influenza in invasive ventilation, admission in Intensive Care Unit (ICU) and deaths. Method: Cross-sectional study with public data from the OpenDataSUS platform, regarding confirmed severe cases for COVID-19 in Brazil in the year 2020. Data were analyzed by SPSS, from the chi-square test of independence and binary logistic regression. Results: The population was 472,688 cases and 177,640 deaths, with a lethality of 37.58% in severe cases. The test of independence was highly significant in vaccinated survivors (<0.0001), and regression showed an almost twofold odds ratio for invasive ventilation, ICU admission, and death in unvaccinated cases. Conclusion: We recommend mass influenza vaccination as an adjuvant in combating the COVID-19 pandemic in Brazil.

Highlights

We wondered if the influenza vaccine is associated with lower mortality in COVID-19? Being the aim of the research to analyze the severe cases of COVID-19 in Brazil in 2020 and compare vaccinated and unvaccinated patients against influenza, in invasive ventilation, admission in Intensive Care Unit (ICU) and deaths
The study population corresponded to 472,688 cases of COVID-19 Severe Acute Respiratory Syndrome (SARS), of which 177,640 died, with a mortality rate in severe cases of 37.58%
All outcomes analyzed were significant in unvaccinated cases, showing that not being vaccinated against influenza has higher chances of ICU admission, invasive ventilation and death, when compared to vaccinated cases (Table 2)

Summary

Introduction

Hypotheses have been raised that the trivalent influenza vaccine may be associated with lower severity and mortality in COVID-19. As well as cross-immunity, due to the structural similarities of the agents, such as the hemagglutinin protein [4] [5] In this context, we wondered if the influenza vaccine is associated with lower mortality in COVID-19? We wondered if the influenza vaccine is associated with lower mortality in COVID-19? Being the aim of the research to analyze the severe cases of COVID-19 in Brazil in 2020 and compare vaccinated and unvaccinated patients against influenza, in invasive ventilation, admission in Intensive Care Unit (ICU) and deaths

Methods

Results

Discussion

Conclusion