Abstract
Primary inoculation tuberculosis is a skin condition that develops at the site of inoculation of Mycobacterium tuberculosis in tuberculosis-free individuals. This report describes the diagnosis, treatment and >1 year follow-up of 30 patients presenting with acupuncture-induced primary inoculation tuberculosis. Our data provide a deeper insight into this rare route of infection of tuberculosis. We also review effective treatment options.
Highlights
Tuberculosis (TB) has existed in humans for millennia [1]
The results showed that susceptibility of Mycobacterium tuberculosis infection in these patients is not affected by glucocorticoids
Primary inoculation tuberculosis is an infection of Mycobacterium tuberculosis, which usually results from direct introduction of the bacterium into the skin of a tuberculosis-free person
Summary
Tuberculosis (TB) has existed in humans for millennia [1]. It is estimated that approximately one third of the world’s population is infected with Mycobacterium tuberculosis which causes 8.8 million new cases of tuberculosis accounting for approximately 1.1 million deaths each year [2]. Prior to receiving regular anti-tuberculosis drugs therapy, all seven confirmed cases had ulcerative lesions, which formed sinus tracts. One confirmed and eight suspected patients presenting with minor wounds or no ulcerative primary lesions received anti-tuberculosis drugs alone. Four confirmed and ten suspected patients with moderate responses to drug therapies were in group II Their skin lesions were healed between two and four months after the quadruple anti-tuberculosis treatment (RFP/ INH/PZA/EMB) started, and the therapy was replaced by two anti-tuberculosis drugs (RFP/INH) for 8–9 months. Seven (3 confirmed and 4 suspected) patients with poor responses to drug therapies were in group III Their skin lesions were healed between four and six months after the quadruple antituberculosis drugs (RFP/INH/PZA/EMB) were treated, and this therapy was replaced by two anti-tuberculosis drugs (RFP/ INH) for 12 months.
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