Analysis of 11,553 art pregnancies to identify female and male factors contributing to adverse art outcome

Abstract

ObjectiveTo assess what factors in the male or the female may contribute to adverse outcomes in ART, as measured as clinical pregnancy loss from a large database of 11,553 ART clinical pregnancies.DesignRetrospective analysis of data was undertaken, using regression analysis to assess which covariates independently and significantly affected clinical pregnancy loss.Materials and MethodsThe ART database of pregnancies from 1992 to 2009 was reviewed. The outcome measures: clinical pregnancy loss, blighted ovum and fetal heart rate abortions were determined.Adjustment for covariates (female age, year of treatment, ovulatory dysfunction, type of treatment) was performed.ResultsOf the 11553 ART pregnancies, clinical pregnancy loss was 2317 (16.4%).Female age and years of treatment and ovulatory dysfunction showed a statistically significant effect (P<0.001) on clinical pregnancy loss, (OR 1.24, 0.98,1.34 respectively).The type of treatment, (FET, fresh IVF/ICSI, ovulation induction and Intrauterine Insemination) showed no effect on clinical pregnancy loss.ConclusionOur data analysis suggests that none of the male infertility factors explored had any significant effect on the ART clinical pregnancy loss.Age, years of ART treatment and ovulatory dysfunction were independent and significant contributors to clinical pregnancy loss. ObjectiveTo assess what factors in the male or the female may contribute to adverse outcomes in ART, as measured as clinical pregnancy loss from a large database of 11,553 ART clinical pregnancies. To assess what factors in the male or the female may contribute to adverse outcomes in ART, as measured as clinical pregnancy loss from a large database of 11,553 ART clinical pregnancies. DesignRetrospective analysis of data was undertaken, using regression analysis to assess which covariates independently and significantly affected clinical pregnancy loss. Retrospective analysis of data was undertaken, using regression analysis to assess which covariates independently and significantly affected clinical pregnancy loss. Materials and MethodsThe ART database of pregnancies from 1992 to 2009 was reviewed. The outcome measures: clinical pregnancy loss, blighted ovum and fetal heart rate abortions were determined.Adjustment for covariates (female age, year of treatment, ovulatory dysfunction, type of treatment) was performed. The ART database of pregnancies from 1992 to 2009 was reviewed. The outcome measures: clinical pregnancy loss, blighted ovum and fetal heart rate abortions were determined. Adjustment for covariates (female age, year of treatment, ovulatory dysfunction, type of treatment) was performed. ResultsOf the 11553 ART pregnancies, clinical pregnancy loss was 2317 (16.4%).Female age and years of treatment and ovulatory dysfunction showed a statistically significant effect (P<0.001) on clinical pregnancy loss, (OR 1.24, 0.98,1.34 respectively).The type of treatment, (FET, fresh IVF/ICSI, ovulation induction and Intrauterine Insemination) showed no effect on clinical pregnancy loss. Of the 11553 ART pregnancies, clinical pregnancy loss was 2317 (16.4%). Female age and years of treatment and ovulatory dysfunction showed a statistically significant effect (P<0.001) on clinical pregnancy loss, (OR 1.24, 0.98,1.34 respectively). The type of treatment, (FET, fresh IVF/ICSI, ovulation induction and Intrauterine Insemination) showed no effect on clinical pregnancy loss. ConclusionOur data analysis suggests that none of the male infertility factors explored had any significant effect on the ART clinical pregnancy loss.Age, years of ART treatment and ovulatory dysfunction were independent and significant contributors to clinical pregnancy loss. Our data analysis suggests that none of the male infertility factors explored had any significant effect on the ART clinical pregnancy loss.