Abstract

Objective To investigate the relationship between obstructive sleep apnea syndrome (OSAS) and metabolic syndrome (MS) in snoring people in government employees. Methods A total of 546 snoring official participants received physical examination in Jiangsu Province Geriatrics Hospital from October 2007 to April 2009, were brought into the research with cluster sampling. Questionnaire survey was performed firstly. All participants were divided into 2 groups according to Epworth sleepiness scale (ESS): normal group(group Ⅰ): ESS<9 and abnormal group (group Ⅱ): ESS≥9. The first 175 participants received polysomnography (PSG) test. Linear regression analysis and multivariate Logistic regression analysis were used for statistics. Results (1)The median of ESS was 5(0-20). Of all 546 participants, 398 (72.9%) were in group Ⅰand 148 (27.1%) were in group Ⅱ. (2)Linear regression analysis showed: constituent ratio of MS=0.1433+ 0.0337×ESS(r2=0.7414, P=0.000), the constituent ratio of MS increased 3.37% when ESS scores increased 1. There was statistical significance difference in constituent ratio of MS between the two groups(χ2=4.605, P=0.032). (3)175 participants received PSG test and the apnea hypopnea index (AHI) was 0.3-90.0/h. The median of AHI was 34.2/h. Pearson correlation analysis showed ESS was linearly correlated with AHI (r=0.721, P=0.000). In all of the participants, there were 50 definite OSAS patients (AHI≥5/h+ ESS≥9), 118 high risk of OSAS participants (AHI≥5/h+ ESS<9), and 7 exclusion OSAS participants(AHI<5/h). Correlation analysis between AHI and HOMA-IR showed that the mean value of HOMA-IR in definite OSAS group was significantly higher than that of in the other two groups(P<0.01 and P<0.05, respectively). (4)Multivariate Logistic regression analysis showed that the major factors affecting MS were body mass index (OR=2.303, P=0.000), AHI(OR=1.083, P=0.004) and mean SpO2 (OR=0.443, P=0.039). Conclusion The government employees with OSAS have higher risk of MS and more serious insulin resistance and need treatment early. Key words: Metabolic syndrome; Insulin resistance; Obstructive sleep apnea syndrome

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