Analysis for Early Experimental Examination on Neonatal Septicemia in 173 Cases

Abstract

Objective To study the characteristics of early laboratory tests on neonatal septicemia. Methods This was a prospective observational study with institutional ethics approval and written maternal consent. There were 3111 cases of clinical medical records of neonatal were selected from neonatal intensive care unit (NICU)of BaYi Children's Hospital in the General Military Hospital of Beijing from January 2009 to December 2010. a total of 173 neonates with neonatal septicemia were included in neonatal septicemia group (n=173)and the others included in control group(n=2938). The blood samples were collected from neonates for blood routine test and routine biochemical analysis, There had no significance difference between two groups among gender, birth weight, mode of delivery, gestational age at delivery, etc.(P>0.05). The relationship between neonatal septicemia related risk factors and results of blood routine test and routine biochemical analysis were analyzed by multivariate non-conditional logistic regression. Results Compared with the control group, hemoglobin (Hb), platelet (PLT), mean corpuscular volume (MCV), blood glucose (Glu)in neonatal septicemia group were significantly lower than those in control group (P<0.05), but C-reacting protein (CRP), total bilirubin (TBIL), direct bilirubin (DBIL), lactate (LAC), blood urea nitrogen (BUN) in neonatal septicemia group were significantly higher than those in control group (P<0.05). Multivariate non-conditional logistic regression analysis on risk factors of neonatal septicemia was used further, dependent variable, covariates were PLT, Hb, MCV, CRP, TBIL, DBIL, BUN, Glu, LAC, the results showed those close correlation risk factors of neonatal septicemia including: PLT, MCV, CRP, TBIL, BUN, Glu and LAC (OR=0.744-1.512, 95%CI: 0.631-1.772; P<0.05). Conclusions The higher of CRP, TBIL, LAC, BUN values and the lower of PLT, MCV, Glu vales, the greater of the risk of neonatal septicemia. It is necessary to take effective treatment measures as soon as possible. Key words: neonatal; septicemia; C-reacting protein; platelet; lactate