Abstract

Pandemic curves, such as COVID-19, often show multiple and unpredictable contamination peaks, often called second, third and fourth waves, which are separated by wide plateaus. Here, by considering the statistical inhomogeneity of age groups, we show a quantitative understanding of the different behaviour rules to flatten a pandemic COVID-19 curve and concomitant multi-peak recurrence. The simulations are based on the Verhulst model with analytical generalized logistic equations for the limited growth. From the log–lin plot, we observe an early exponential growth proportional to et/τgrow. The first peak is often τgrow ≅ 5 d. The exponential growth is followed by a recovery phase with an exponential decay proportional to e−t/τrecov. For the characteristic time holds: τgrow< τrecov. Even with isolation, outbreaks due to returning travellers can result in a recurrence of multi-peaks visible on log–lin scales. The exponential growth for the first wave is faster than for the succeeding waves, with characteristic times, τ of about 10 d. Our analysis ascertains that isolation is an efficient method in preventing contamination and enables an improved strategy for scientists, governments and the general public to timely balance between medical burdens, mental health, socio-economic and educational interests.

Highlights

  • Received: 31 March 2021Accepted: 29 April 2021Published: 2 May 2021Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.The current COVID-19 pandemic curves are routinely used to investigate and inform governments, healthcare professionals and society on, essentially, the dynamics of contaminations and deaths in a nation

  • One reliable and widely verified model of limited growth is the generalized logistic equation proposed by Verhulst [2]

  • The shape of curves in the logarithmic representation is indicative of the tangent lines in the run up to exponential growth and exponential decay in the recovery phase

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Summary

Introduction

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The current COVID-19 pandemic curves are routinely used to investigate and inform governments, healthcare professionals and society on, essentially, the dynamics of contaminations and deaths in a nation. Pandemic curves are presented for several countries on a semi-logarithmic scale and normalized per 105 inhabitants, either on the number of infections or on the number of deaths per day, d [1]. Limited growth models are mathematical tools employed to describe growth in pandemic scenarios, among others. One reliable and widely verified model of limited growth is the generalized logistic equation proposed by Verhulst [2]. In the Verhulst model, N(t) represents the cumulative number of infected peo

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