Abstract
Head and neck tumors account for 30% of malignant tumors in the body, which is a key topic in the world. The comparative data of radiotherapy, surgical therapy or chemotherapy for the treatment of these diseases are given. The treatment of epidermal growth factor receptor inhibitor, cyclin dependent kinase inhibitor and insulin-like growth factor receptor inhibitor were analyzed. It is pointed out that molecular targeted therapy is a targeted blocker to interfere with the signal transduction pathway, which is regulated by the specific molecule and is closely related to the occurrence of tumor, so as to inhibit tumor growth and metastasis.
Highlights
It has been found that malignant tumors are more dangerous and difficult to cure
Squamous cell carcinoma of the head and neck refers to squamous cell carcinoma that occurs in the lips, hypopharynx, oropharynx and oral cavity, with a high mortality rate of[1,2,3].Early patients with head and neck squamous cell carcinoma usually get good results after surgical treatment, but because of the lack of understanding of this type of tumor, most patients come to visit, their condition has developed to the local late stage[2].The related literature showed that the majority of patients with head and neck tumors were advanced type and local advanced tumors, and the proportion of them was between 70% and 80%.These diseases are generally treated with radiotherapy, chemotherapy and surgery
In contrast to radiotherapy and chemotherapy, the application of targeted therapy brings a break through to the treatment of patients [4].In the course of actual tumor targeting therapy, the use of its drugs is based on its mechanism of action, and the use of drugs is based on the characteristics of the disease [5,6].Such as: cetuximab, erlotinib and bevacizumab, etc
Summary
It has been found that malignant tumors are more dangerous and difficult to cure. As far as tumor types are concerned, head and neck tumors are the fifth most common malignant tumor in the world [1].The occurrence frequency of this tumor is relatively high in China, and the most common type of tumor is head and neck squamous cell carcinoma. The long-term survival rate of patients with advanced tumors was increased by about 20%, and the effect of treatment was not good [3].Third, during the course of radiotherapy and chemotherapy, the patients’ salivary glands in their inability to eat smoothly or completely, leading to the gradual deterioration of the patient’s body, such as malnutrition, poor resistance, and so on. The most typical problem in patients after treatment is local recurrence after treatment [7,8].Local recurrence is an important cause of death in the head and neck cancer. Because of the importance of preservation of anatomical structure and organ function, the treatment of head and neck cancer is very complicated [12]
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