Analysis and investigation on the Kaschin-Beck disease in Shanxi Province in 2008

Abstract

Objective To master the status of Kaschin-Beck disease(KBD) in children and adults, assess the effect of prevention, and provide scientific basis for control strategies. Methods Based on history data, children aged 7-12 years in 10 heavy KBD villages of 10 counties of 8 cities were clinically examined and the X-Ray of right hand examination was conducted. Clinical examinations were carried out in the people over 16 years in 65 heavy KBD villages of 37 counties of 10 cities. One village was respectively selected in four directions of Xunyi countyto supply selenium(Se). The content of Se in hair of the 30 children aged 7 - 12 years was detected before and six months after the supplement of Se in each village. And the content of Se in selenium-iodine salt was detected in 30 families of each village. Results Among the 862 children, no cases beyond 1 degree were detected in the clinical examination. One out of 862 children had pathological changes in metaphysis and the detectable rate of X-Ray was 0.21%(1/862). Total 30 599 people in 65 villages were examined, aceounting for 88.56%(30 599/ 35 638). The total detectable rate of KBD was 16.69%(5108/30 599), and the detectable rate of Ⅰ degree, Ⅱ degree, Ⅲ degree was 9.73% (2977/30 599),5.4%(1652/30 599), 1.57% (479/30 599), respectively. The patients aged 36～60 years accounted for 65.7%(3355/5108) of the total patients. The eontent of Se was (5.43±3.19) mg/kg and (7.74±1.81)mg/kg respectively in the period before and 6 months after the supplement, and the content of Se in hair of children was (0.3933±0.0930)mg/kg and (0.3613±0.0997)mg/kg, respectively. Conclusions KBD in children is in a steady decrease in Shanxi, but the situation of KBD in adults is serious. The treatment for the adult KBD patients should be carried out actively, and health education should be strengthened to consolidate the achievements of prevention and control of the KBD. Key words: Kaschin-Beck disease; Selenium; Children; Adults; Epidemiological monitoring; Outcome assessment