Abstract
Chromatographic properties and chemical stability of 12 kinds of phenolic compounds Z. schinifolium were investigated and analyzed to use as an antioxidant substance in dentifrices. Twelve compounds were completely separated under 0.01% phosphoric acid-acetonitrile gradient condition at 20°C and detected by photodiode array detector. Each compound showed good linearity at optimized wavelength, and showed good precision and accuracy in dentifrices. Using this analytical method, phenolic compounds in Z. schinifolium fraction and dentifrices were successfully determined. Caffeic acid, quercetin, and xanthoxylin decomposed in aqueous solution, and other compounds were preserved over 94%. It was better to store phenolic compounds under weak acidic conditions (<pH 6) to prevent the decomposition of phenolic compounds. Mixed in dentifrices, about half of the total compounds remained for 45 d, but the preservation rate (%) showed big differences between each compound. Each fraction of Z. schinifolium -containing dentifrice was manufactured and analyzed. In Z. schinifolium dentifrices, 44% of phenolic compounds remained after 2 mo.
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