Analysis and comparison of glucose concentration between capillary and venous glucose in fasting or postprandial state

Abstract

Objective To analyze and compare the difference between the finger capillary blood glucose (CBG), capillary plasma glucose (CPG), venous blood glucose (VBG) and venous plasma glucose (VPG) in fasting or 2-hour postprandial state. Methods One hundred and forty patients with type 1 or type 2 Diabetes Mellitus patients (56 males and 84 females with mean age(54±10)years and 82 patients with fasting and 58 with 2-hour postprandial glucose) were included in this study. Four different blood samples were measured for each patient simultaneously. CBG and VBG was measured using One Touch Verio blood glucose monitoring system. CPG and VPG was measured using YSI 2300 glucose analyzer as a reference method. A clinical evaluation of accuracy of One Touch Verio glucose monitoring system was conducted. Results The accuracy of Verio blood glucose monitoring system met the requirements of ISO 15197 (2003) standard. In fasting state, CBG and VBG which detected by blood glucose monitoring system was (6.7±2.4) mmol/L and (6.7±2.3) mmol/L, respectively. The relative error was 0.40%(t=0.62, P>0.05). CPG and VPG which detected by YSI was (6.4±2.5) mmol/L and (6.4±2.4) mmol/L, respectively. The relative error was 0.25%(t=0.39, P>0.05). CBG were slightly higher than VPG. The relative error was 5.89%(P<0.05). In 2-hour postprandial state, CBG and VBG were (8.5±3.6) mmol/L and (7.9±3.6) mmol/L, respectively. The relative error was 7.58%(t=9.55, P<0.05). CPG and VPG was (8.1±3.8) mmol/L and (7.6±3.8) mmol/L, respectively. The relative error was 6.08%(t=10.9, P<0.05). CBG was obviously higher than VPG. The relative error was 11.6%, P<0.01. Conclusions One Touch Verio glucose monitoring system is suitable for clinical monitoring of blood glucose and also for SMBG, the fasting CBG values are close to those of the VPG. The postprandial CBG values are higher than those of the VPG. Key words: Diabetes mellitus; Blood glucose; Blood glucose monitoring