Abstract
(1) Background: The purpose of this study was to determine the association among thyroid cancer, osteoporosis and fracture history. (2) Methods: The data collected from 2004 through 2016 for the Korean Genome and Epidemiology Study were retrieved. For a total of 1349 participants with thyroid cancer and 163,629 control participants, the odds ratios (ORs) with 95% confidence intervals (CIs) of osteoporosis and fracture history were evaluated using a logistic regression model. (3) Results: The adjusted ORs of osteoporosis comparing thyroid cancer with the control group were 1.41 (95% CI = 1.18–1.70, p < 0.001) for all participants and 1.43 (95% CI = 1.19–1.71, p < 0.001) for women. The adjusted ORs of fracture history comparing these two groups were not significantly associated within the entire group of participants, men only or women only. (4) Conclusions: The adjusted OR of osteoporosis was significantly higher than 1, comparing thyroid cancer with the control group, especially in women. The adjusted OR of fractures was not significantly higher than 1, comparing the thyroid cancer group with the control group.
Highlights
Osteoporosis is a bone disease that is characterized by the loss of bone mass and strength, which lead to fragility fractures and severe morbidities and mortality
The aim of this study was to evaluate the association among thyroid cancer, osteoporosis and fractures based on Korean Genome and Epidemiology Study (KoGES) health examinee (HEXA) data
The mean age was lower (52.3 years vs. 53.0 years) in the thyroid cancer group compared with the control group with statistical significance (Table 1)
Summary
Osteoporosis is a bone disease that is characterized by the loss of bone mass and strength, which lead to fragility fractures and severe morbidities and mortality. The prevalence of osteoporosis and osteopenia in the US is 35.5 million in women and 18.2 million in men [1]. Approximately 50% of females and 20% of males experience fragility fractures of the hip, wrist or spine in their aged life [2]. In Korea, the prevalence of osteoporosis was reported to be 38.0% in females and 7.3% in males aged over 50 years old [3]. The main causes of osteoporosis are related to age, calcium deficiency, vitamin D deficiency, secondary hyperparathyroidism, inflammatory diseases such as rheumatoid arthritis, glucocorticoid use, excessive alcohol use and estrogen deficiency, especially in postmenopausal women [4,5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International journal of environmental research and public health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
