[Analyses of risk factors for temporarily inhibited parathyroid hormone secretion of postoperative primary hyperparathyroidism].

Abstract

Objective: To study relative risk factors for temporarily inhibited parathyroid hormone (PTH) secretion after surgery of primary hyperparathyroidism (PHPT). Methods: Seventy-two cases with PHPT from October 2017 to March 2019 in Beijing Chaoyang Hospital were analyzed retrospectively, including 22 males and 50 females aged from 13 to 83 years old. They were reviewed and divided into a complete inhibition group (24 cases, PTH=0 pg/ml), an incomplete inhibition group (23 cases, 0<PTH<12.4 pg/ml), and a non-inhibition group (25 cases, PTH≥12.4 pg/ml) according to the PTH level on the first day after surgery of PHPT. With the Kruskal-Wallis multi-group rank sum test and the Nemenyi test, preoperative and postoperative biochemical parameters and endocrine indexes, including the preoperative serum levels of calcium, phosphorus, PTH, 25-hydroxyvitamin D, and alkaline phosphatase, as well as the levels of PTH 10 min after focal resection, calcium on the first day after surgery, and PTH on the third day after surgery, were compared among three groups to evaluate potential risk factor for postoperative temporary inhabitation of PTH secretion. The predictive values of various risk factors for postoperative temporary inhibition of PTH secretion were evaluated with ROC curve analysis. Results: Preoperative serum PTH, calcium levels, and serum calcium level on the first day after surgery in the complete inhibition group were higher than those in the non-inhibition group,respectively, with statically significant differences [256.5(141.6,585.3) pg/ml vs. 130.2(92.1,256.6) pg/ml, 2.90(2.69,3.22) mmol/L vs. 2.61(2.50,2.75) mmol/L, 2.23(2.08,2.41) mmol/L vs. 2.12(2.05,2.14) mmol/L, χ(2) were 7.17, 11.90, 8.32, respectively, all P<0.05]. When the preoperative serum calcium level was higher than 2.62 mmol/L (AUC=0.698, 95%CI: 0.57-0.83, P=0.006) or the preoperative PTH level was higher than 115.9 pg/ml (AUC=0.697, 95%CI: 0.58-0.82, P=0.007), patients tended to inhibit completely PTH secretion after operation. Conclusions: Preoperative serum calcium and PTH levels are risk factors for postoperative temporary PTH inhibition in PHPT.