Abstract
“Brain natriuretic peptide” (BNP) wordt gebruikt in de humane geneeskunde voor de diagnose van congestief hartfalen. Vermits er geen BNP-test voor paarden beschikbaar is, werd BNP nog nooit bepaald bij paarden. Op basis van de 90% homologie tussen equine en porciene BNP, werd in de voorliggende studie het plasma BNP-gehalte van gezonde paarden (groep 1; n=20), paarden met een hartaandoening zonder (groep 2a; n=8) en met atriale dilatatie (n=8), ventriculaire dilatatie (n=1) of beide (n=1) (groep 2b; n=10) bepaald met een porciene BNP “enzyme-linked immunoassay” (ELISA). Er werd geen significant verschil gevonden tussen de BNP-concentratie van groep 1 (77,79; 37,20-513,36 pg/mL), groep 2a (52,02; 24,69-268,37 pg/mL) of 2b (94,73; 42,88-470,66 pg/mL). In deze pilootstudie wordt aangetoond dat deze porciene BNP ELISA-test geen accurate detectie van BNP bij paarden toelaat. Een specifieke equine BNP-test zou dus ontwikkeld moeten worden om de BNP-concentratie bij paarden te meten.
Highlights
Natriuretic peptides (NPs) have become an essential aid to establish a proper diagnosis and prognosis and to monitor patients with heart failure (Dickstein et al, 2008)
Atrial NPs are mainly secreted in case of atrial dilatation (Hayek and Nemer, 2010; Hori et al, 2011; Trachsel et al, 2012), while brain NPs are more related with ventricular pathologies (Goetze, 2004)
The horses were classified into two subgroups: group 2a included the horses with valvular regurgitation without cardiac dilatation and group 2b included the horses with valvular regurgitation and either atrial dilatation or ventricular dilatation or both
Summary
Natriuretic peptides (NPs) have become an essential aid to establish a proper diagnosis and prognosis and to monitor patients with heart failure (Dickstein et al, 2008). Atrial and brain NPs are the two most important members of the NP family, which contains a typical 17-amino acid ring closed by a disulfide binding between two cysteine-molecules (Stein and Levin, 1998) Both atrial and brain NPs are released in case of cardiac dilatation and subsequently broken down into a stable, inactive NH2-terminal molecule (NT-proANP and NT-proBNP) and an unstable, active molecule (ANP and BNP). Atrial NPs are mainly secreted in case of atrial dilatation (Hayek and Nemer, 2010; Hori et al, 2011; Trachsel et al, 2012), while brain NPs are more related with ventricular pathologies (Goetze, 2004) Due to their longer half-life, brain NPs are often preferred for the diagnosis of heart failure in human clinical practice (Woodard and Rosado, 2007; Ray et al, 2008). A half-life of 2-5 min (Ruskoaho, 1992) and of 55-60 min (Ikeda et al, 2007) have been reported for human ANP and NT-proANP, respectively, while BNP and NT-proBNP have a halflife of 12-20 min and 60-120 min, respectively (Pemberton et al, 2000; Kemperman et al, 2004; Kimura et al, 2007; Kroll et al, 2007)
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