Abstract
Analogs of biologically active compounds IX. Synthesis of several new uracil and pteridine 6-aza-analogs based on cyclization of arylhydrazones derived from mesoxalic acid
Highlights
Certain 1,2,4‐triazines and pyrimido[1,2,4]triazines can be considered as analogues of naturally occurring N‐heterocycles, especially of pyrimidine bases, purines and pteridines
From the literature only phenyl derivative 3a is known and it was described as an azocompound,17,18 we have proven it exists in a hydrazono form on the basis of the NMR spectra measured in DMSO‐d6
We have successfully developed a method for the preparation of several new 5C and 5N substituted 3‐oxo‐2‐ phenyl‐1,2,4‐triazine‐6‐carbonitriles and 8‐imino‐2‐arylpyrimido[4,5‐e][1,2,4]triazine‐3,6(2H,5H)‐diones, which represent uracil and pteridine 6‐azaanalogs
Summary
Certain 1,2,4‐triazines and pyrimido[1,2,4]triazines can be considered as analogues of naturally occurring N‐heterocycles, especially of pyrimidine bases, purines and pteridines.
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