Abstract
To define more precisely the telolysosome-autophagosome-autolysosome interaction during glucagon-induced autophagy in rat liver, a conceptual and mathematical model has been developed as the first step in simulation of particle behavior during the autophagic response. The present first approximation model is based on previous experimental studies, collision theory and chemical kinetics. An examination of model formulation has revealed no serious difficulties in the assumptions made and further refinement seems possible with the development of methods for quantitatively evaluating specific particle populations.
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