Abstract
A model for the pharmacokinetic disposition of salicylate following the acute ingestion of a toxic dose of salicylate was programmed for an analog computer. Rate constants for the model were assigned according to published data on the dose-dependent nature of salicylate kinetics. The model was considered to be a valid characterization of acute salicylate ingestion since computer-simulated curves provide a close visual fit to time-dependent body and urine salicylate level data from previous studies of salicylate-intoxicated children. Analog simulation of salicylate ingestion and subsequent disposition has the potential to more accurately predict the course of the toxicity than currently used methods.
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