Abstract
Objective: Patients with anorexia nervosa (AN) are at increased risk of ventricular arrhythmias, which are considered to be associated with QT interval prolongation. The aims of this study was to analyse the QT interval in patients with AN considering the potential impact of pharmacotherapy and to verify various QT correction formulas. Method: Fifty-six patients hospitalized with AN (average age: 22.8±5.6 years; F/M: 54/2, mean BMI=13.6±2.6 kg/m2) were enrolled to analysis: Group non-D (n=44; 78,6%) included patients, who did not use drugs that prolong the QT interval, group D (n=12; 21,4%) included patients, who were treated with such drugs. QT intervals were measured in a 12-lead ECG and corrected using the four formulas: Bazett, Fridericia, Framingham and Hodges. Results: Mean heart rate (HR) was similar in both groups (61±16.3 bpm in group D vs 63.1±18.7 bpm in non-D, p > 0.05). Pathological bradycardia (HR < 50 bpm) was present in 5 patients (41.7%) in group D and in 13 patients (29.5%) in group non-D. QTc interval corrected with Framingham formula was longer in Group-D (459±81ms) vs non D-group (413±33ms) p=0.04. QT interval corrected with Bazett and Hodges formulas was significantly dependent on HR (R= -0.29, p=0.03 and R= -0.42, p=0.001, respectively). Influence of HR on results of Fridericia and Framingham formulas was not significant (R = -0.22, p=0.1 and R = -0.11, p=0.4). Conclussions: Information about pharmacotherapy in AN patients is key for QTc assessment. Choice of correction formula has impact on the QTc. QTc obtained using Framingham and Fridericia formulas were the least dependent on heart rate.
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