Analgesic Nephropathy due to Diclofenac in a 24-year-old Indian Male Patient: A Case Report

Abstract

Analgesics are commonly prescribed first line agent for the treatment of rheumatological disorders like rheumatoid arthritis and ankylosing spondylitis. Renal toxicities are known adverse reactions of analgesics, however, acute onset renal injury due to analgesics in rheumatological disorders is not currently known. Here we describe a case of a 24-yearold Indian male patient who was diagnosed with ankylosing spondylitis three years back and was prescribed tablet Diclofenac 150 mg in three divided doses per day. The patient presented with breathlessness, pedal edema and decreased urine output on 24th February 2019. The patient was diagnosed to have bilateral End Stage Renal Disease (ESRD) with small kidneys, pulmonary edema and left ventricular dysfunction using echocardiography. The patient was symptomatically treated and later transferred for renal transplant. Renal toxicity of analgesics is known but is usually reported after years of exposure. This case is first of the kind of occurrence of ESRD within three years of exposure. This case highlights the need for monitoring in patients who are prescribed analgesics for a long duration especially in patients of rheumatological disorders. Key words: Diclofenac, Nephropathy, Analgesic, Ankylosing spondylitis, Young.